Preferred Label : Cytotoxic T-Lymphocyte;
NCIt synonyms : Cytotoxic T-Lymphocytes; T-Lymphocytes, Cytotoxic; CTL; Cytolytic T-Cell; Cytotoxic T Cells; Cytotoxic T Cell;
NCIt related terms : cytotoxic T lymphocyte; T-Lymphocyte, Cytotoxic; killer T cell;
NCIt definition : Immunized T-lymphocytes which can directly destroy appropriate target cells. These
cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC),
in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft,
tumor cell or virally transformed or chemically modified target cell. These cells
are distinct from natural killer cells and from killer cells mediating antibody-dependent
cell cytotoxicity.;
Alternative definition : NCI-GLOSS: A type of immune cell that can kill certain cells, including foreign cells,
cancer cells, and cells infected with a virus. Cytotoxic T lymphocytes can be separated
from other blood cells, grown in the laboratory, and then given to a patient to kill
cancer cells. A cytotoxic T lymphocyte is a type of white blood cell and a type of
lymphocyte.;
Codes from synonyms : CDR0000634810; CDR0000634067; CDR0000045664;
Origin ID : C12543;
UMLS CUI : C0039195;
Anatomic structure is physical part of
- Associated anatomy of gene products
- Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- Cell [UMLS semantic type]
- UMLS correspondences (same concept)
- cell_type_or_tissue_affected_by_chemical_or_drug
- concept_is_in_subset
- is_normal_cell_origin_of_disease
- may_be_normal_cell_origin_of_disease
- tissue_is_expression_site_of_gene_product
