Pooled Mutant KRAS-Targeted Long Peptide Vaccine

Preferred Label : Pooled Mutant KRAS-Targeted Long Peptide Vaccine;

NCIt synonyms : KRAS Peptide Vaccine; Pooled Mutant KRAS Peptide Vaccine;

NCIt definition : A peptide vaccine containing a mixture of long peptides that are derived from tumor-specific mutant forms of the KRAS (K-ras) antigen, with potential immunostimulatory and antitumor activities Upon administration of the pooled mutant KRAS-targeted long peptide vaccine, the KRAS peptides may stimulate the host immune system to mount a cytotoxic T-cell lymphocyte (CTL)-mediated immune response against KRAS-expressing tumor cells. KRAS, a tumor-associated antigen (TAA) that plays a key role in the RAS/mitogen-activated protein kinase (MAPK) signaling pathway, is overexpressed on a variety of tumor cell types.;

NCI Metathesaurus CUI : CL978789;

Details

Origin ID

C165638;

UMLS CUI

C5237331;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Oncogene K-Ras [NCIt concept]

Keyword's position in hierarchy(ies) :

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