Preferred Label : Pooled Mutant KRAS-Targeted Long Peptide Vaccine;
NCIt synonyms : KRAS Peptide Vaccine; Pooled Mutant KRAS Peptide Vaccine; mKRASvax; Synthetic Long Peptide Mutant KRAS Vaccine; Mutated KRAS Peptide-Poly-ICLC Vaccine mKRASvax; Mutant KRAS Peptide-Hiltonol Vaccine mKRASvax; SLP mKRASvax; KRAS G12D/G12R/G12V/G12A/G12C/G13D Peptide-Poly-ICLC Vaccine mKRASvax;
NCIt definition : A cancer vaccine containing a mixture of synthetic long peptides (SLPs) targeting
six KRAS mutations, including KRAS G12D, G12R, G12V, G12A, G12C and G13D, and the
adjuvant poly-ICLC, with potential immunostimulatory and antineoplastic activities.
Upon administration, pooled mutant KRAS-targeted long peptide vaccine may stimulate
the immune system to mount a cytotoxic T-lymphocyte (CTL) response against KRAS G12D/G12R/G12V/G12A/G12C/G13D-expressing
tumor cells. KRAS, a member of the RAS family of oncogenes, plays an important role
in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive
signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.;
NCI Metathesaurus CUI : CL978789;
Origin ID : C165638;
UMLS CUI : C5237331;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
