" /> Oncogene K-Ras - CISMeF





Preferred Label : Oncogene K-Ras;

NCIt synonyms : Oncogene, K-Ras-2; KRAS; v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog; KRAS2; Oncogene, K-Ras; Ki-RAS; RASK2;

NCIt definition : Human Oncogene K-Ras is a mutated variant of KRAS2 Gene, which encodes two alternative isoforms of monomeric p21 K-RAS protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. K-Ras is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, mutations of specific amino acids activate RAS to transform cells. KRAS is involved in malignancy much more often than is HRAS. Oncogene K-Ras disrupts normal cell function.;

GenBank Accession Number : M54968;

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26/04/2024


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