Preferred Label : KRAS Mutant Inhibitor ALTA3263;
NCIt synonyms : KRAS Inhibitor ALTA3263; KRAS Isoform-selective Inhibitor ALTA3263; Pan-KRAS Inhibitor ALTA3263;
NCIt definition : An orally bioavailable non-covalent dual ON/OFF state inhibitor of multiple oncogenic
KRAS mutant forms, including KRAS G12V, G12D and G12C, with potential antineoplastic
activity. Upon oral administration, KRAS mutant inhibitor ALTA3263 selectively targets
and binds to KRAS, thereby inhibiting KRAS-dependent signaling. This inhibits the
growth and survival of KRAS-overexpressing and mutated tumor cells. KRAS, a member
of the RAS family of oncogenes, plays an important role in cell signaling, division
and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell growth, proliferation, invasion, and metastasis.;
Molecule name : ALTA-3263; ALTA 3263;
Origin ID : C215829;
concept_is_in_subset
- has_target
