Preferred Label : KRAS Mutant Inhibitor KQB365;
NCIt synonyms : KRAS Inhibitor KQB365;
NCIt definition : An inhibitor of one or more KRAS mutations, with potential antineoplastic activity.
Upon administration, KRAS mutant inhibitor KQB365 targets, binds to and inhibits one
or more KRAS mutations, thereby inhibiting KRAS mutant-dependent signaling. This inhibits
the proliferation of and induces apoptosis in tumor cells in which KRAS is mutated.
KRAS plays an important role in cell signaling, division and differentiation. Mutations
of KRAS may induce constitutive signal transduction leading to tumor cell growth,
proliferation, invasion, and metastasis.;
Molecule name : KQB 365; KQB-365;
Origin ID : C214501;
concept_is_in_subset
- has_target
