Preferred Label : Pan-KRAS Inhibitor LY4066434;
NCIt synonyms : KRAS Inhibitor LY4066434;
NCIt definition : An orally bioavailable non-covalent inhibitor that targets the oncogenic KRAS wild-type
(WT) and various KRAS mutant forms, including KRAS G12D, G12V, G12C, G13D, G12A, and
G12S, with potential antineoplastic activity. Upon oral administration, pan-KRAS Inhibitor
LY4066434 selectively targets and binds to KRAS, thereby inhibiting KRAS-dependent
signaling. This inhibits the growth and survival of KRAS-overexpressing and mutated
tumor cells. KRAS, a member of the RAS family of oncogenes, plays an important role
in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive
signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.;
Molecule name : LY 4066434; LY-4066434;
Origin ID : C213206;
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