Preferred Label : Pan-KRAS Inhibitor YL-17231;
NCIt synonyms : Pan-KRAS Mutant Inhibitor YL-17231; RAS Inhibitor YL-17231;
NCIt definition : An orally bioavailable inhibitor of various KRAS mutations, such as the oncogenic
KRAS substitution mutations G12C, G12D and G12V, with potential antineoplastic activity.
Upon oral administration, pan-KRAS inhibitor YL-17231 targets, binds to and inhibits
various forms of KRAS mutations, thereby inhibiting KRAS-dependent signaling. This
inhibits the proliferation of and induces apoptosis in tumor cells in which KRAS is
mutated. KRAS plays an important role in cell signaling, division and differentiation.
Mutations of KRAS may induce constitutive signal transduction leading to tumor cell
growth, proliferation, invasion, and metastasis.;
Molecule name : YL 17231; TEB-17231; TEB 17231; YL-17231;
Origin ID : C202009;
concept_is_in_subset
- has_target
