Autologous Anti-ROR1 CAR T-cells LYL797NCIt concept
Preferred Label : Autologous Anti-ROR1 CAR T-cells LYL797;
NCIt synonyms : Autologous ROR1-targeted CAR T-cells LYL797;
NCIt definition : A preparation of genetically and epigenetically reprogrammed autologous T-lymphocytes
transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting
the receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential immunomodulatory
and antineoplastic activities. After isolation, transduction, and expansion in culture,
the autologous anti-ROR1 CAR T-cells LYL797 are reintroduced into the patient and
are directed to tumor cells expressing ROR1, which may result in a selective toxicity
against, and lysis of ROR1-expressing tumor cells. ROR1 is expressed during embryogenesis
and upregulated in certain tumor types. High levels of ROR1 expression often correlate
with poor prognosis. Due to the genetically and epigenetically modifications, LYL797
may overcome T-cell exhaustion and inability to self-renew. The T-cells are genetically
modified to overexpress the protein c-Jun and thereby resist exhaustion and restore
their anti-tumor activity. Also, the T-cells are reprogrammed to give them durable
stemness and effector function.;