Tyrosine-Protein Kinase Transmembrane Receptor ROR1

Preferred Label : Tyrosine-Protein Kinase Transmembrane Receptor ROR1;

NCIt synonyms : Receptor Tyrosine Kinase-Like Orphan Receptor-1; NTRKR1; Neurotrophic Tyrosine Kinase Receptor-Related 1; ROR1; EC 2.7.10.1; Receptor Tyrosine Kinase-Like Orphan Receptor 1; Neurotrophic Tyrosine Kinase, Receptor-Related 1;

NCIt definition : Tyrosine-protein kinase transmembrane receptor ROR1 (937 aa, 104 kDa) is encoded by the human ROR1 gene. This protein plays a role in receptor type tyrosine kinase-mediated signaling.;

Details

Origin ID

C29879;

UMLS CUI

C0211525;

Currated CISMeF NLP mapping
- receptor tyrosine kinase-like orphan receptor 1 [MeSH concept]
OMIM relation
- Receptor tyrosine kinase-like orphan receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ROR1 protein, human [MeSH Supplementary Concept]
- ROR1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- ROR1 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Frizzled Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Kringle Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Anti-ROR1 Antibody-drug Conjugate CS5001 [NCIt concept]
- Anti-ROR1/Anti-CD3 Bispecific Antibody EMB-07 [NCIt concept]
- Anti-ROR1/CD3 T-cell Engager NVG-111 [NCIt concept]
- Anti-ROR1/PNU-159682 Derivative Antibody-drug Conjugate NBE-002 [NCIt concept]
- Autologous Anti-ROR1 CAR T-cells LYL797 [NCIt concept]
- Autologous Anti-ROR1 CAR-T Cells BMS-986403 [NCIt concept]
- Autologous Anti-ROR1 CAR-T Cells ONCT-808 [NCIt concept]
- Autologous Anti-ROR1 CAR-mbIL15-Safety Switch/Intrinsic PD-1 Blockade T-cells PRGN-3007 [NCIt concept]
- Nebratamig [NCIt concept]
- Zilovertamab [NCIt concept]
- Zilovertamab Vedotin [NCIt concept]

Keyword's position in hierarchy(ies) :

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