Preferred Label : CD16-based ROR1-targeted NK Cell Engager PBA-0405;
NCIt definition : An engineered natural killer (NK) cell engager comprised of an anti-receptor tyrosine
kinase-like orphan receptor 1 (ROR1) antibody, with an increased binding affinity
to CD16 Fc receptor, with potential immunostimulating and antineoplastic activities.
Upon administration, CD16-based ROR1-targeted NK cell engager PBA-0405 targets and
binds to ROR1 expressed on tumor cells and simultaneously binds to the activating
CD16 Fc receptor expressed on NK cells, thereby bringing ROR1-expressing tumor cells
and NK cells together. This stimulates the NK cells, and results in the selective
NK cell-mediated tumor cell lysis of ROR1-expressing tumor cells and antibody-dependent
cellular cytotoxicity (ADCC). CD16, also known as Fc-gamma receptor III, is normally
expressed on the surface of NK cells, neutrophils, monocytes and macrophages, and
plays a key role in initiating ADCC. It is often downregulated in certain cancers,
thereby inhibiting the anti-tumor immune response. ROR1, also known as neurotrophic
tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and
in various hematological and solid malignancies. It plays key roles in tumor cell
proliferation and survival.;
Molecule name : PBA-0405; PBA 0405;
NCI Metathesaurus CUI : CL1928799;
Origin ID : C206691;
concept_is_in_subset
- has_target
