Preferred Label : Anti-ROR1 Antibody-drug Conjugate CS5001;
NCIt synonyms : Anti-ROR1 ADC CS5001;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed
against the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor
1 (ROR1) that is site-specifically conjugated with a tumor-cleavable beta-glucuronide
linker to a tumor-cleavable prodrug of pyrrolobenzodiazepine (PBD) dimer, with potential
antineoplastic activity. Upon intravenous administration, the monoclonal antibody
moiety of anti-ROR1 ADC CS5001 targets and binds to ROR1 expressed on tumor cells.
Upon binding and internalization, both the linker and prodrug are selectively cleaved
by lysosomal b-glucuronidase overexpressed in tumor cells. Free PBD is released and
forms highly cytotoxic DNA interstrand cross-links, thereby blocking cell division
and killing ROR1-expressing cancer cells. ROR1, also known as neurotrophic tyrosine
kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in various
hematological and solid malignancies. It plays key roles in tumor cell proliferation
and survival.;
Molecule name : ABL-202; ABL 202; LCB 71; CS-5001; CS 5001; LCB-71;
NCI Metathesaurus CUI : CL1792026;
Origin ID : C187106;
UMLS CUI : C5706352;
Semantic type(s)
- concept_is_in_subset
- has_target
