Preferred Label : Anti-ROR1 Antibody-drug Conjugate IM-1021;
NCIt synonyms : Anti-ROR1 ADC IM-1021; Anti-ROR1/HC74 ADC IM-1021; Anti-ROR1/Topoisomerase-1 Inhibitor ADC IM-1021;
NCIt definition : An antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal
antibody directed against the tumor-associated antigen (TAA) receptor tyrosine kinase-like
orphan receptor 1 (ROR1) conjugated, via a cleavable linker, to the camptothecin derivative
and topoisomerase 1 inhibitor HC74, with potential antineoplastic activity. Upon administration,
the monoclonal antibody moiety of anti-ROR1 ADC IM-1021 targets and binds to ROR1
expressed on tumor cells. Upon binding, internalization and binder cleavage, HC74
is released. HC74 inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of ROR1-expressing tumor cells. IM-1021 is also able to induce a bystander effect
on neighboring cells in the tumor environment. This further inhibits the proliferation
of tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related
1 (NTRKR1), is expressed during embryogenesis and in various hematological and solid
malignancies. It plays key roles in tumor cell proliferation and survival.;
Molecule name : ZPC 21; ZPC-21; IM-1021; IM 1021;
Origin ID : C217105;
concept_is_in_subset
- has_target
