Preferred Label : Anti-ROR1/Anti-CD3/Anti-HSA Trispecific Antibody NM32-2668;
NCIt synonyms : ROR1 x CD3 x HSA T-cell Engager NM32-2668; ROR1-targeting TCE NM32-2668; ROR1 x CD3 x HSA TCE NM32-2668; ROR1 x CD3 x HSA Trispecific Antibody NM32-2668; Anti-ROR1/CD3/HSA Trispecific Antibody NM32-2668;
NCIt definition : A trispecific antibody directed against the tumor-associated antigen (TAA) receptor
tyrosine kinase-like orphan receptor 1 (ROR1), the T-cell surface antigen CD3 and
human serum albumin (HSA), with potential immunostimulating and antineoplastic activities.
Upon administration, anti-ROR1/anti-CD3/anti-HSA trispecific antibody NM32-2668 binds
to both ROR1 expressed on tumor cells and CD3 expressed on cytotoxic T-lymphocytes
(CTLs). This activates and redirects CTLs to ROR1-expressing tumor cells, which results
in the CTL-mediated death of ROR1-expressing tumor cells. Anti-ROR1/anti-CD3/anti-HSA
trispecific antibody NM32-2668 also binds to HSA, which prolongs the half-life of
the agent. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1),
is expressed during embryogenesis and in many types of hematological malignancies.
It plays key roles in tumor cell proliferation and survival.;
Molecule name : NM32-2668; NM32 2668;
NCI Metathesaurus CUI : CL1927614;
Origin ID : C205353;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
