NCIt definition : A bispecific antibody directed against both the tumor-associated antigen (TAA) receptor
tyrosine kinase-like orphan receptor 1 (ROR1) and the T-cell surface antigen CD3,
with potential immunostimulating and antineoplastic activities. Upon administration,
anti-ROR1/anti-CD3 bispecific antibody EMB-07 binds to both ROR1 expressed on tumor
cells and CD3 expressed on cytotoxic T-lymphocytes (CTLs). This activates and redirects
CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing
tumor cells. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1
(NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies.
It plays key roles in tumor cell proliferation and survival.;
Semantic type(s)