Preferred Label : Zilovertamab Vedotin;
NCIt synonyms : Antibody-drug Conjugate VLS-101; Anti-ROR1 ADC VLS-101;
NCIt definition : An antibody-drug conjugate (ADC) composed of zilovertamab, a humanized, immunoglobulin
G (IgG1) monoclonal antibody against the tumor-associated antigen (TAA) receptor tyrosine
kinase-like orphan receptor 1 (ROR1) conjugated, via a proteolytically cleavable linker,
to the auristatin derivative and microtubule-disrupting cytotoxic agent monomethyl
auristatin E (MMAE), with potential antineoplastic activity. Upon intravenous administration,
the monoclonal antibody moiety of zilovertamab vedotin targets and binds to ROR1 expressed
on tumor cells. Upon binding, internalization and proteolytic cleavage, MMAE binds
to tubulin and inhibits its polymerization, which results in G2/M phase arrest and
induces apoptosis in ROR1-expressing tumor cells. ROR1, also known as neurotrophic
tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and
by certain leukemias. It plays key roles in tumor cell proliferation and survival.;
UNII : IZY9ZSI6FI;
CAS number : 2376463-48-6;
Molecule name : VLS-101; VLS 101; MK-2140;
NCI Metathesaurus CUI : CL937381;
Origin ID : C157772;
UMLS CUI : C5667180;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_target
