Zilovertamab - CISMeF

Preferred Label : Zilovertamab;

NCIt synonyms : Cirmtuzumab;

NCIt definition : A humanized monoclonal antibody against the extracellular domain of the human receptor tyrosine kinase-like orphan receptor 1 (ROR1), with potential antineoplastic activity. Upon administration, zilovertamab binds to ROR1 and blocks ROR1-mediated signaling. This prevents tumor cell proliferation in cancer cells overexpressing ROR1. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is normally expressed during embryogenesis. It is overexpressed in certain leukemias and solid tumors, but minimally expressed in healthy cells.;

UNII : FEH7RQ7B3J;

CAS number : 2485779-13-1;

Molecule name : UC-961;

NCI Metathesaurus CUI : CL474136;

Details

Origin ID

C118284;

UMLS CUI

C3899620;

Currated CISMeF NLP mapping
- Zilovertamab [SMS substance]
- cirmtuzumab [MeSH Supplementary Concept]
- cirmtuzumab [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- cirmtuzumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tyrosine-Protein Kinase Transmembrane Receptor ROR1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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