NCIt definition : A humanized monoclonal antibody against the extracellular domain of the human receptor
tyrosine kinase-like orphan receptor 1 (ROR1), with potential antineoplastic activity.
Upon administration, zilovertamab binds to ROR1 and blocks ROR1-mediated signaling.
This prevents tumor cell proliferation in cancer cells overexpressing ROR1. ROR1,
also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is normally
expressed during embryogenesis. It is overexpressed in certain leukemias and solid
tumors, but minimally expressed in healthy cells.;
UNII : FEH7RQ7B3J;
CAS number : 2485779-13-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2485779-13-1
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