Kringle Domain

Preferred Label : Kringle Domain;

NCIt synonyms : Kringle;

NCIt definition : Kringles are autonomous structural domains, found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity. Kringle domains are characterised by a triple loop, 3-disulphide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies, in some serine proteases and plasma proteins.;

Details

Origin ID

C13290;

UMLS CUI

C0064417;

Associated anatomy of gene products
- Apolipoprotein(a) [NCIt concept]
Currated CISMeF NLP mapping
- kringles [MeSH Descriptor]
- kringles [MeSH concept]
Semantic type(s)
- Spatial Concept [UMLS semantic type]
UMLS correspondences (same concept)
- kringles [MeSH concept]
- kringles [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- Angiostatin [NCIt concept]
- Coagulation Factor XII [NCIt concept]
- Hepatocyte Growth Factor [NCIt concept]
- Hepatocyte Growth Factor Activator [NCIt concept]
- Hepatocyte Growth Factor-Like Protein [NCIt concept]
- Plasminogen [NCIt concept]
- Prothrombin [NCIt concept]
- Tissue-Type Plasminogen Activator [NCIt concept]
- Tyrosine-Protein Kinase Transmembrane Receptor ROR1 [NCIt concept]
- Tyrosine-Protein Kinase Transmembrane Receptor ROR2 [NCIt concept]
- Urokinase-Type Plasminogen Activator [NCIt concept]

Keyword's position in hierarchy(ies) :

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