Angiostatin - CISMeF

Preferred Label : Angiostatin;

NCIt synonyms : PLG; Kringles 1-4 of Plasminogen;

NCIt definition : Angiostatin (388, 40 kDa) is encoded by the human PLG gene. This protein fragment is involved in the inhibition of blood vessel formation.;

Alternative definition : NCI-GLOSS: A protein normally made by the body. It can also be made in the laboratory, and is being studied in the treatment of cancer. Angiostatin may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.;

NCIt note : Angiostatin is comprised of the first four Kringle structural elements found in plasminogen.;

Codes from synonyms : 31865; CDR0000378185;

Details

Origin ID

C17910;

UMLS CUI

C3887700;

Automatic exact mappings (from CISMeF team)
- Plasminogen [OMIM gene]
- plasminogen [ORDO Gene]
Currated CISMeF NLP mapping
- angiostatins [MeSH Descriptor]
- angiostatins [MeSH concept]
OMIM relation
- Plasminogen [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
gene_encodes_gene_product
- PLG Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_expressed_in_tissue
- Kidney [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Fragment [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Kringle Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_physical_part_of
- Plasminogen [NCIt concept]
gene_product_plays_role_in_biological_process
- Angiogenic Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Metastasis Suppression [NCIt concept]
- Negative Regulation of Angiogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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