Preferred Label : Prothrombin;
NCIt synonyms : EC 3.4.21.5; Factor II; Coagulation Factor II; Prothrombin Gene Product; F2;
NCIt definition : Prothrombin (622 aa, 70 kDa) is encoded by the human F2 gene. This protein plays
a role in both coagulation and proteolysis of fibrinogen.;
NCIt note : Prothrombin catalyzes the cleavage of Arg-Gly bonds in fibrinogen to form fibrin and
release fibrinopeptides A and B. (UniProt); Prior to secretion, prothrombin is modified to have gamma-carboxyglutamyl residues,
resulting from the carboxylation of glutamyl residues by vitamin K-dependent gamma-carboxylase.
These modified residues are necessary for the calcium-dependent interaction with a
negatively charged phospholipid surface, which is essential for the conversion of
prothrombin to thrombin. (UniProt); Prothrombin activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin,
protein C. (UniProt); Prothrombin protein can be cleaved into the following 4 chains: activation peptide
fragment 1, activation peptide fragment 2, thrombin light chain, thrombin heavy chain.
(UniProt);
NCI Metathesaurus CUI : CL449006;
Origin ID : C82854;
UMLS CUI : C5552806;
Automatic exact mappings (from CISMeF team)
- OMIM relation
- See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
- endogenous_product_related_to
- gene_encodes_gene_product
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
