Apolipoprotein(a)

Preferred Label : Apolipoprotein(a);

NCIt synonyms : Lp(a); Apo(a); EC 3.4.21.-; LPA; Antiangiogenic AK38 Protein;

NCIt definition : Apolipoprotein(a) (4548 aa, 501 kDa) is encoded by the human LPA gene. This protein is involved in the regulation of thrombosis and lipid metabolism.;

NCIt note : Lipoprotein(a) (Lp(a)) is formed by the disulfide linkage of apolipoprotein B100 (APOB) of a low-density lipoprotein particle to apolipoprotein(a). (OMIM); Apolipoprotein(a) (apo(a)) is proteolytically cleaved, to form mini-Lp(a). These apo(a) fragments may accumulate in atherosclerotic lesions and promote thrombogenesis. O-glycosylation of apo(a) may limit proteolytic fragmentation. The shared homology of mini-Lp(a) with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, as the fragments may compete with plasminogen for fibrin(ogen) binding. (UniProt);

NCI Metathesaurus CUI : CL538292;

Details

Origin ID

C140118;

UMLS CUI

C4553379;

Automatic exact mappings (from CISMeF team)
- Apolipoprotein [MedDRA Preferred Term]
- Apolipoprotein (substance) [SNOMED CT concept]
- Apolipoprotein E [LOINC component]
- Apolipoprotein e [OMIM gene]
- Apolipoprotein(a) [OMIM Phenotype]
- Lipoprotein a [LOINC component]
- Lipoprotein(a) [OMIM gene]
- Logopenic progressive aphasia [ORDO Disease]
- O-phosphoserine trna-selenocysteine trna synthase [OMIM gene]
- apolipoprotein E [ORDO Gene]
- apolipoproteins [MeSH Descriptor]
- apolipoproteins [MeSH concept]
- apolipoproteins e [MeSH Descriptor]
- lipid transporter activity [GO term]
- lipoprotein(a) [HGNC gene]
- lipoprotein(a) [MeSH Descriptor]
- obsolete apolipoprotein [GO term]
- the a apolipoprotein [medical devices type]
OMIM relation
- Apolipoprotein(a) [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- LPA Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Kringle Domain [NCIt concept]
gene_product_has_biochemical_function
- Lipoprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Hydrolysis [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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