Preferred Label : apolipoproteins e;
MeSH definition : A class of protein components which can be found in several lipoproteins including
HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized
in most organs, Apo E is important in the global transport of lipids and cholesterol
throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that
mediates the binding, internalization, and catabolism of lipoprotein particles in
cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or
defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.;
MeSH synonym : apo-e; apoe; apo e;
MeSH Hyperonym : apoproteins E; Apoprotein (E);
MeSH hyponym : apolipoprotein E isoproteins; Isoproteins, Apolipoprotein E; Apo E Isoproteins; Isoproteins, Apo E;
Is substance : O;
Origin ID : D001057;
UMLS CUI : C0003595;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- COG1410 [MeSH Supplementary Concept]
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
A class of protein components which can be found in several lipoproteins including
HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized
in most organs, Apo E is important in the global transport of lipids and cholesterol
throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that
mediates the binding, internalization, and catabolism of lipoprotein particles in
cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or
defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
