Hepatocyte Growth Factor-Like Protein

Preferred Label : Hepatocyte Growth Factor-Like Protein;

NCIt synonyms : Hepatocyte Growth Factor-Like; Macrophage Stimulating Protein; Macrophage-Stimulating Protein; Macrophage Stimulatory Protein; Hepatocyte Growth Factor-Like Protein Homolog; MSP;

NCIt definition : Hepatocyte growth factor-like protein (711 aa, 80 kDa) is encoded by the human MST1 gene. This protein plays a role in the positive regulation of both macrophage activation and ciliary motility.;

NCIt note : Hepatocyte growth factor-like protein resembles S1 family peptidases. It has 4 kringle domains and an inactive S1 peptidase domain.; Hepatocyte growth factor-like protein is cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. Hepatocyte growth factor-like protein appears to be a ligand for the receptor tyrosine kinase, macrophage-stimulating protein receptor (RON).;

Details

Origin ID

C131153;

UMLS CUI

C1567781;

Automatic exact mappings (from CISMeF team)
- Macrophage stimulating 1 [OMIM gene]
- community health centers [MeSH Descriptor]
- macrophage stimulating 1 [ORDO Gene]
- macrophage stimulating protein [MeSH Supplementary Concept]
- macrophage stimulating protein [MeSH concept]
- microseminoprotein beta [ORDO Gene]
OMIM relation
- Macrophage stimulating 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MST1 protein, human [MeSH concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- MST1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_structural_domain_or_motif
- Kringle Domain [NCIt concept]
gene_product_is_element_in_pathway
- Macrophage Stimulating 1 Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Myeloid Cell Activation Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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