Preferred Label : Macrophage Stimulating 1 Receptor Signaling Pathway;
NCIt related terms : Msp/Ron Receptor Signaling Pathway;
Alternative definition : BIOCARTA: MSP, macrophage-stimulating protein, acts through the transmembrane receptor
kinase RON (Stk in mice) to play a role in inflammation and the response to tissue
injury. MSP is secreted by the liver into the blood as pro-MSP, an inactive precursor
form. MSP is related to clotting factors that are activated by proteolytic cleavage
and pro-MSP is itself also activated by cleavage to MSP. Binding of activated MSP
heterodimer to RON expressed on macrophages, monocytes and keratinocytes stimulates
activation of the RON kinase and second messenger pathways, including PI-3 kinase.
Macrophages respond to MSP with changes in cell shape and motility and keratinocytes
respond by proliferating. Tissue injury leads to pro-MSP cleavage and activation,
and macrophages and keratinocytes that respond to MSP are key cells in tissue injury
response, supporting a role for MSP and RON in the response to tissue injury. The
interaction of MSP and macrophages at sites of inflammation such as infection also
depends on chemotactic factors such as MCP1 and inflammatory cytokines such as IL-1
and TNF that attract and activate immune cells in the affected tissue. (This definition
may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_mspPathway;
Origin ID : C39157;
UMLS CUI : C1518152;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
