C-C Motif Chemokine 2

Preferred Label : C-C Motif Chemokine 2;

NCIt synonyms : CCL2; Monocyte Chemoattractant Protein-1; Monocyte Chemotactic Protein-1; Monocyte Chemotactic and Activating Protein; Monocyte Secretory Protein JE; Small Inducible Cytokine A2; MCAF; HC11; MCP-1; Small Inducible Cytokine-A2; Monocyte Chemoattractant Protein 1; Monocyte Chemotactic and Activating Factor; Small-Inducible Cytokine A2; Monocyte Chemotactic Protein 1;

NCIt definition : C-C motif chemokine 2 (99 aa, 11 kDa) is encoded by the human CCL2 gene. This protein plays a role in monocyte and basophil chemotaxis.;

NCIt note : C-C motif chemokine 2 binds to chemokine receptors CCR2 and CCR4.;

Details

Origin ID

C20909;

UMLS CUI

C1449159;

Currated CISMeF NLP mapping
- monocyte chemoattractant protein 1 (66-77) [MeSH concept]
- monocyte chemoattractant protein 1 (66-77) [MeSH Supplementary Concept]
- monocyte chemoattractant protein 1 (9-76) [MeSH concept]
- monocyte chemoattractant protein 1 (9-76) [MeSH Supplementary Concept]
OMIM relation
- Chemokine, CC motif, ligand 2 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CCL2 protein, human [MeSH concept]
- CCL2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CC Cytokine Gene [NCIt concept]
- CCL2 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- CCR5 Signaling Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL23-Mediated Signaling Pathway [NCIt concept]
- LDL Pathway [NCIt concept]
- Macrophage Stimulating 1 Receptor Signaling Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]
is_target
- Carlumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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