Preferred Label : Carlumab;
NCIt synonyms : Anti-human Small-inducible Cytokine A2 Monoclonal Antibody CNTO 888; Immunoglobulin G1, anti-(human monocyte chemoattractant protein-1) (human monoclonal
CNTO888 gamma 1-chain), disulfide with human monoclonal CNTO888 kappa-chain, dimer; Anti-CCL2 Human Monoclonal Antibody CNTO 888;
NCIt definition : A human IgG1 kappa monoclonal antibody directed against human CC chemokine ligand
2 (CCL2) with potential antineoplastic activity. Carlumab binds to and inhibits CLL2,
which may result in inhibition of angiogenesis and, so, tumor cell proliferation.
Endothelium-derived CLL2 (monocyte chemoattractant protein; MCP1) is a member of the
beta-chemokine family, can stimulate monocyte/macrophage migration and smooth muscle
cell (SMC) proliferation, and plays a role in angiogenesis and tumor cell migration;
CCL2 induction of angiogenesis may involve the upregulation of hypoxia-inducible factor
1 alpha (HIF-1 alpha) gene expression which, in turn, induces vascular endothelial
growth factor-A (VEGF-A) gene expression.;
UNII : 6TC1BB2EV9;
CAS number : 915404-94-3;
Molecule name : CNTO 888;
Chemical formula : C6442H9966N1706O2018S40;
Origin ID : C71010;
UMLS CUI : C2346793;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
