" /> Carlumab - CISMeF





Preferred Label : Carlumab;

NCIt synonyms : Anti-human Small-inducible Cytokine A2 Monoclonal Antibody CNTO 888; Immunoglobulin G1, anti-(human monocyte chemoattractant protein-1) (human monoclonal CNTO888 gamma 1-chain), disulfide with human monoclonal CNTO888 kappa-chain, dimer; Anti-CCL2 Human Monoclonal Antibody CNTO 888;

NCIt definition : A human IgG1 kappa monoclonal antibody directed against human CC chemokine ligand 2 (CCL2) with potential antineoplastic activity. Carlumab binds to and inhibits CLL2, which may result in inhibition of angiogenesis and, so, tumor cell proliferation. Endothelium-derived CLL2 (monocyte chemoattractant protein; MCP1) is a member of the beta-chemokine family, can stimulate monocyte/macrophage migration and smooth muscle cell (SMC) proliferation, and plays a role in angiogenesis and tumor cell migration; CCL2 induction of angiogenesis may involve the upregulation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression which, in turn, induces vascular endothelial growth factor-A (VEGF-A) gene expression.;

UNII : 6TC1BB2EV9;

CAS number : 915404-94-3;

Molecule name : CNTO 888;

Chemical formula : C6442H9966N1706O2018S40;

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07/05/2025


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