Chemokine Signaling Pathway

Preferred Label : Chemokine Signaling Pathway;

Alternative definition : KEGG: Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.;

KEGG ID : hsa04062;

Details

Origin ID

C91487;

UMLS CUI

C2984298;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- Beta-Adrenergic Receptor Kinase 1 [NCIt concept]
- Beta-Adrenergic Receptor Kinase 2 [NCIt concept]
- Beta-Arrestin-1 [NCIt concept]
- Beta-Arrestin-2 [NCIt concept]
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- C-C Chemokine Receptor Type 1 [NCIt concept]
- C-C Chemokine Receptor Type 10 [NCIt concept]
- C-C Chemokine Receptor Type 2 [NCIt concept]
- C-C Chemokine Receptor Type 3 [NCIt concept]
- C-C Chemokine Receptor Type 4 [NCIt concept]
- C-C Chemokine Receptor Type 5 [NCIt concept]
- C-C Chemokine Receptor Type 6 [NCIt concept]
- C-C Chemokine Receptor Type 7 [NCIt concept]
- C-C Chemokine Receptor Type 8 [NCIt concept]
- C-C Chemokine Receptor Type 9 [NCIt concept]
- C-C Motif Chemokine 1 [NCIt concept]
- C-C Motif Chemokine 13 [NCIt concept]
- C-C Motif Chemokine 14 [NCIt concept]
- C-C Motif Chemokine 15 [NCIt concept]
- C-C Motif Chemokine 16 [NCIt concept]
- C-C Motif Chemokine 17 [NCIt concept]
- C-C Motif Chemokine 18 [NCIt concept]
- C-C Motif Chemokine 19 [NCIt concept]
- C-C Motif Chemokine 2 [NCIt concept]
- C-C Motif Chemokine 20 [NCIt concept]
- C-C Motif Chemokine 21 [NCIt concept]
- C-C Motif Chemokine 22 [NCIt concept]
- C-C Motif Chemokine 23 [NCIt concept]
- C-C Motif Chemokine 24 [NCIt concept]
- C-C Motif Chemokine 25 [NCIt concept]
- C-C Motif Chemokine 26 [NCIt concept]
- C-C Motif Chemokine 27 [NCIt concept]
- C-C Motif Chemokine 28 [NCIt concept]
- C-C Motif Chemokine 3 [NCIt concept]
- C-C Motif Chemokine 3-Like 1 [NCIt concept]
- C-C Motif Chemokine 4 [NCIt concept]
- C-C Motif Chemokine 5 [NCIt concept]
- C-C Motif Chemokine 7 [NCIt concept]
- C-C Motif Chemokine 8 [NCIt concept]
- C-X-C Chemokine Receptor Type 1 [NCIt concept]
- C-X-C Chemokine Receptor Type 2 [NCIt concept]
- C-X-C Chemokine Receptor Type 3 [NCIt concept]
- C-X-C Chemokine Receptor Type 4 [NCIt concept]
- C-X-C Chemokine Receptor Type 5 [NCIt concept]
- C-X-C Chemokine Receptor Type 6 [NCIt concept]
- C-X-C Motif Chemokine 10 [NCIt concept]
- C-X-C Motif Chemokine 11 [NCIt concept]
- C-X-C Motif Chemokine 13 [NCIt concept]
- C-X-C Motif Chemokine 14 [NCIt concept]
- C-X-C Motif Chemokine 16 [NCIt concept]
- C-X-C Motif Chemokine 2 [NCIt concept]
- C-X-C Motif Chemokine 3 [NCIt concept]
- C-X-C Motif Chemokine 5 [NCIt concept]
- C-X-C Motif Chemokine 6 [NCIt concept]
- C-X-C Motif Chemokine 9 [NCIt concept]
- CX3C Chemokine Receptor 1 [NCIt concept]
- Chemokine XC Receptor 1 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Cytokine SCM-1 Beta [NCIt concept]
- Dedicator of Cytokinesis Protein 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Engulfment and Cell Motility Protein 1 [NCIt concept]
- Eotaxin [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Forkhead Box Protein O3 [NCIt concept]
- Fractalkine [NCIt concept]
- G Protein-Coupled Receptor Kinase 4 [NCIt concept]
- G Protein-Coupled Receptor Kinase 5 [NCIt concept]
- G Protein-Coupled Receptor Kinase 6 [NCIt concept]
- G Protein-Coupled Receptor Kinase 7 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Alpha [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Growth-Regulated Alpha Protein [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV3 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-11 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-12 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Beta-5 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Interleukin-8 [NCIt concept]
- Lymphotactin [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Beta [NCIt concept]
- Neural Wiskott-Aldrich Syndrome Protein [NCIt concept]
- Nuclear Factor NF-kappa-B p105 Subunit [NCIt concept]
- Partitioning Defective 3 Homolog [NCIt concept]
- Paxillin [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 1 Protein [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Platelet Factor 4 [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Kinase C Delta Type [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- RAS-Related Protein Rap-1A [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- Rho-Associated Protein Kinase 2 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- SHC-Transforming Protein 2 [NCIt concept]
- SHC-Transforming Protein 3 [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- Signal Transducer and Activator of Transcription 2 [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Stromal Cell-Derived Factor 1 [NCIt concept]
- T-Lymphoma Invasion and Metastasis-Inducing Protein 1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tyrosine-Protein Kinase Fgr [NCIt concept]
- Tyrosine-Protein Kinase Hck [NCIt concept]
- Tyrosine-Protein Kinase ITK/TSK [NCIt concept]
- Tyrosine-Protein Kinase JAK2 [NCIt concept]
- Tyrosine-Protein Kinase JAK3 [NCIt concept]
- Tyrosine-Protein Kinase Lyn [NCIt concept]
- Wiskott-Aldrich Syndrome Protein [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARRB1 wt Allele [NCIt concept]
- ARRB2 wt Allele [NCIt concept]
- BCAR1 wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CCL1 wt Allele [NCIt concept]
- CCL11 wt Allele [NCIt concept]
- CCL13 wt Allele [NCIt concept]
- CCL14 wt Allele [NCIt concept]
- CCL15 wt Allele [NCIt concept]
- CCL16 wt Allele [NCIt concept]
- CCL17 wt Allele [NCIt concept]
- CCL18 wt Allele [NCIt concept]
- CCL19 wt Allele [NCIt concept]
- CCL2 wt Allele [NCIt concept]
- CCL20 wt Allele [NCIt concept]
- CCL21 wt Allele [NCIt concept]
- CCL22 wt Allele [NCIt concept]
- CCL23 wt Allele [NCIt concept]
- CCL24 wt Allele [NCIt concept]
- CCL25 wt Allele [NCIt concept]
- CCL26 wt Allele [NCIt concept]
- CCL27 wt Allele [NCIt concept]
- CCL28 wt Allele [NCIt concept]
- CCL3 wt Allele [NCIt concept]
- CCL3L1 wt Allele [NCIt concept]
- CCL4 wt Allele [NCIt concept]
- CCL5 wt Allele [NCIt concept]
- CCL7 wt Allele [NCIt concept]
- CCL8 wt Allele [NCIt concept]
- CCR1 wt Allele [NCIt concept]
- CCR10 wt Allele [NCIt concept]
- CCR2 wt Allele [NCIt concept]
- CCR3 wt Allele [NCIt concept]
- CCR4 wt Allele [NCIt concept]
- CCR5 wt Allele [NCIt concept]
- CCR6 wt Allele [NCIt concept]
- CCR7 wt Allele [NCIt concept]
- CCR8 wt Allele [NCIt concept]
- CCR9 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- CX3CL1 wt Allele [NCIt concept]
- CX3CR1 wt Allele [NCIt concept]
- CXCL1 wt Allele [NCIt concept]
- CXCL10 wt Allele [NCIt concept]
- CXCL11 wt Allele [NCIt concept]
- CXCL12 wt Allele [NCIt concept]
- CXCL13 wt Allele [NCIt concept]
- CXCL14 wt Allele [NCIt concept]
- CXCL16 wt Allele [NCIt concept]
- CXCL2 wt Allele [NCIt concept]
- CXCL3 wt Allele [NCIt concept]
- CXCL5 wt Allele [NCIt concept]
- CXCL6 wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- CXCL9 wt Allele [NCIt concept]
- CXCR1 wt Allele [NCIt concept]
- CXCR2 wt Allele [NCIt concept]
- CXCR3 wt Allele [NCIt concept]
- CXCR4 wt Allele [NCIt concept]
- CXCR5 wt Allele [NCIt concept]
- CXCR6 wt Allele [NCIt concept]
- DOCK2 wt Allele [NCIt concept]
- ELMO1 wt Allele [NCIt concept]
- FGR wt Allele [NCIt concept]
- FOXO3 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- GNB1 wt Allele [NCIt concept]
- GNB2 wt Allele [NCIt concept]
- GNB3 wt Allele [NCIt concept]
- GNB5 wt Allele [NCIt concept]
- GNG11 wt Allele [NCIt concept]
- GNG12 wt Allele [NCIt concept]
- GNG2 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GRK2 wt Allele [NCIt concept]
- GRK3 wt Allele [NCIt concept]
- GRK4 wt Allele [NCIt concept]
- GRK5 wt Allele [NCIt concept]
- GRK6 wt Allele [NCIt concept]
- GRK7 wt Allele [NCIt concept]
- GSK3A wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HCK wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- ITK wt Allele [NCIt concept]
- JAK2 wt Allele [NCIt concept]
- JAK3 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LYN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NFKBIB wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PARD3 wt Allele [NCIt concept]
- PF4 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PREX1 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PRKCD wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PTK2B wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RAP1A wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- ROCK2 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SHC2 wt Allele [NCIt concept]
- SHC3 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- STAT2 wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]
- TIAM1 wt Allele [NCIt concept]
- VAV1 wt Allele [NCIt concept]
- VAV2 wt Allele [NCIt concept]
- VAV3 wt Allele [NCIt concept]
- WAS wt Allele [NCIt concept]
- WASL wt Allele [NCIt concept]
- XCL1 wt Allele [NCIt concept]
- XCL2 wt Allele [NCIt concept]
- XCR1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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