Stromal Cell-Derived Factor 1

Preferred Label : Stromal Cell-Derived Factor 1;

NCIt synonyms : PBSF; SDF-1; Pre-B Cell Growth Stimulating Factor; hIRH; Chemokine (C-X-C Motif) Ligand 12; CXCL12; hSDF-1beta; Stromal Cell-Derived Factor-1; C-X-C Motif Chemokine 12; hSDF-1; IRH; SDF-1-Beta(1-72); Intercrine Reduced In Hepatomas; Pre-B Cell Growth-Stimulating Factor; SDF1;

NCIt definition : Stromal cell-derived factor 1 (93 aa, 11 kDa) is encoded by the human CXCL12 gene. This protein is involved in signal transduction and chemotaxis of T-lymphocytes, and monocytes.;

NCIt note : There are at least 7 isoforms of stromal cell-derived factor 1, which are products of alternative splicing.;

Details

Origin ID

C28774;

UMLS CUI

C1528383;

OMIM relation
- Chemokine, cxc motif, ligand 12 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CXCL12 protein, human [MeSH concept]
- CXCL12 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CXC Cytokine Gene [NCIt concept]
- CXCL12 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- Axon Guidance Pathway [NCIt concept]
- CCR5 Signaling Pathway [NCIt concept]
- CXCR4 Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Migration Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]
is_target
- Dociparstat sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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