cAMP-Dependent Protein Kinase Catalytic Subunit Beta

Preferred Label : cAMP-Dependent Protein Kinase Catalytic Subunit Beta;

NCIt synonyms : cAMP-Dependent Protein Kinase Beta-Catalytic Subunit; cAMP-Dependent Protein Kinase Beta; PKA C-Beta; PRKACB; EC 2.7.11.11; Protein Kinase A C-Beta; Protein Kinase-A C-Beta;

NCIt definition : cAMP-dependent protein kinase catalytic subunit beta (351 aa, 41 kDa) is encoded by the human PRKACB gene. This protein is involved in both protein phosphorylation and cAMP-mediated signal transduction.;

NCIt note : cAMP-dependent protein kinase catalytic subunit gamma is a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates.;

Details

Origin ID

C38412;

UMLS CUI

C1514550;

Automatic exact mappings (from CISMeF team)
- Protein kinase, camp-dependent, catalytic, beta [OMIM gene]
- cyclic AMP-Dependent protein kinase catalytic subunits [MeSH Descriptor]
- protein kinase A calpha [MeSH Supplementary Concept]
- protein kinase A cbeta [MeSH concept]
- protein kinase C beta [MeSH Descriptor]
- protein kinase C beta [MeSH concept]
Currated CISMeF NLP mapping
- cAMP-Dependent protein kinase, beta-Catalytic subunit [MeSH concept]
OMIM relation
- Protein kinase, camp-dependent, catalytic, beta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PRKACB protein, human [MeSH Supplementary Concept]
- PRKACB protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PRKACB Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- AKAP8 in Mitosis Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Attenuation of GPCR Signaling Pathway [NCIt concept]
- BAD Regulation Pathway [NCIt concept]
- CARM1 Transcription Regulation Pathway [NCIt concept]
- CFTR Pathway [NCIt concept]
- CK1/CDK5 Regulation Pathway [NCIt concept]
- CREB Activation Signaling Pathway [NCIt concept]
- CSK Protein Kinase Activation Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Centrosome Pathway [NCIt concept]
- ChREBP Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- G-Protein Signaling Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Gastric Acid Secretion Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Hedgehog Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Nitric Oxide Pathway [NCIt concept]
- Nitric Oxide Signaling Pathway [NCIt concept]
- Olfactory Transduction Pathway [NCIt concept]
- Oocyte Maturation Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- Pain Repression Pathway [NCIt concept]
- Phospholipase C-Epsilon Signaling Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Protein Kinase A Activation Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- Stathmin Pathway [NCIt concept]
- Stress Fiber Formation Pathway [NCIt concept]
- Taste Transduction Pathway [NCIt concept]
- Th2 Cytokine Gene Induction Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
- Vasopressin-Regulated Water Reabsorption Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_is_physical_part_of
- Protein Kinase A [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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