Gap Junction Assembly Pathway

Preferred Label : Gap Junction Assembly Pathway;

NCIt related terms : Gap junction;

Alternative definition : KEGG: Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2 , pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.;

KEGG ID : hsa04540;

Details

Origin ID

C91478;

UMLS CUI

C2984290;

Automatic exact mappings (from CISMeF team)
- Gap junction (cell structure) [SNOMED CT concept]
- gap junction [GO term]
- gap junction [SNOMED Notion]
- gap junctions [MeSH concept]
- gap junctions [MeSH Descriptor]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 5-Hydroxytryptamine Receptor 2A [NCIt concept]
- 5-Hydroxytryptamine Receptor 2C [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Beta-1 Adrenergic Receptor [NCIt concept]
- Beta-2 Adrenergic Receptor [NCIt concept]
- Casein Kinase I Isoform Delta [NCIt concept]
- D(1A) Dopamine Receptor [NCIt concept]
- D(2) Dopamine Receptor [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Gap Junction Alpha-1 Protein [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Guanylate Cyclase Soluble Subunit Alpha-1 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Alpha-2 [NCIt concept]
- Guanylate Cyclase Soluble Subunit Beta-1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 1 [NCIt concept]
- Inositol 1,4,5-Trisphosphate Receptor Type 2 [NCIt concept]
- Metabotropic Glutamate Receptor 1 [NCIt concept]
- Metabotropic Glutamate Receptor 5 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 7 [NCIt concept]
- Platelet-Derived Growth Factor C [NCIt concept]
- Platelet-Derived Growth Factor D [NCIt concept]
- Platelet-Derived Growth Factor Subunit A [NCIt concept]
- Platelet-Derived Growth Factor Subunit B [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Tight Junction Protein ZO-1 [NCIt concept]
- Tubulin Alpha-1B Chain [NCIt concept]
- Tubulin Alpha-3C/D Chain [NCIt concept]
- Tubulin Beta Chain [NCIt concept]
- Tubulin Beta-3 Chain [NCIt concept]
- Tubulin Beta-4A Chain [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
- cGMP-Dependent Protein Kinase 1 [NCIt concept]
- cGMP-Dependent Protein Kinase 2 [NCIt concept]
pathway_has_gene_element
- ADCY9 wt Allele [NCIt concept]
- ADRB1 wt Allele [NCIt concept]
- ADRB2 wt Allele [NCIt concept]
- CSNK1D wt Allele [NCIt concept]
- DRD1 wt Allele [NCIt concept]
- DRD2 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- GJA1 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GRM1 wt Allele [NCIt concept]
- GRM5 wt Allele [NCIt concept]
- GUCY1A1 wt Allele [NCIt concept]
- GUCY1A2 wt Allele [NCIt concept]
- GUCY1B1 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- HTR2A wt Allele [NCIt concept]
- HTR2C wt Allele [NCIt concept]
- ITPR1 wt Allele [NCIt concept]
- ITPR2 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK7 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PDGFA wt Allele [NCIt concept]
- PDGFB wt Allele [NCIt concept]
- PDGFC wt Allele [NCIt concept]
- PDGFD wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PRKG1 wt Allele [NCIt concept]
- PRKG2 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- TJP1 wt Allele [NCIt concept]
- TUBA1B wt Allele [NCIt concept]
- TUBA3C wt Allele [NCIt concept]
- TUBB wt Allele [NCIt concept]
- TUBB3 wt Allele [NCIt concept]
- TUBB4A wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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