Metabotropic Glutamate Receptor 5

Preferred Label : Metabotropic Glutamate Receptor 5;

NCIt synonyms : GRM5; mGluR5; Glutamate Receptor, Metabotropic 5; Metabotropic Glutamate Receptor-5;

NCIt definition : Metabotropic glutamate receptor 5 (1212 aa, 132 kDa) is encoded by the human GRM5 gene. This protein plays a role in both glutamate binding and downstream signal transduction.;

Alternative definition : CDISC: An antigen encoded by the GRM5 gene and is involved in both glutamate binding and downstream signal transduction. It can be considered as an autoantigen and is commonly associated with autoimmune encephalitis.;

NCIt note : L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.;

Details

Origin ID

C26241;

UMLS CUI

C3711735;

Automatic exact mappings (from CISMeF team)
- Glutamate receptor, metabotropic, 5 [OMIM gene]
- glutamate metabotropic receptor 5 [HGNC gene]
- receptor, metabotropic glutamate 5 [MeSH Descriptor]
Currated CISMeF NLP mapping
- receptor, metabotropic glutamate 5 [MeSH concept]
OMIM relation
- Glutamate receptor, metabotropic, 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- GRM5 protein, human [MeSH concept]
- GRM5 protein, human [MeSH Supplementary Concept]
- receptor, metabotropic glutamate 5 [MeSH Descriptor]
- receptor, metabotropic glutamate 5 [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- GRM5 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Phospholipase C Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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