Phospholipase C Signaling Pathway

Preferred Label : Phospholipase C Signaling Pathway;

Alternative definition : BIOCARTA: Phospholipase C comes in multiple forms and plays a key role in the signal transduction process for many receptors. Its main function is to hydrolyze phosphatidylinositol diphosphate into diacylglycerol (DG) and inositol triphosphate (IP3). DG is necessary for further activation of Protein Kinase C while IP3 leads to the release of intracellular calcium. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_plcPathway;

Details

Origin ID

C39194;

UMLS CUI

C1519054;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-11 [NCIt concept]
- Metabotropic Glutamate Receptor 5 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Vasopressin V1B Receptor [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- GNA11 wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- VAV1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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