Preferred Label : PIK3CA wt Allele;
NCIt synonyms : Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide wt Allele; p110-Alpha Gene; Phosphatidylinositol 3-Kinase, Catalytic Subunit Gene; PI3K; PI3K-Alpha Gene; MCMTC; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha wt Allele; CWS5; MCM; Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Alpha Gene; PIK3-Alpha Gene; CLOVE; MCAP;
NCIt definition : Human PIK3CA wild-type allele is located in the vicinity of 3q26.3 and is approximately
36 kb in length. This allele, which encodes phosphatidylinositol-4,5-bisphosphate
3-kinase catalytic subunit alpha isoform protein, plays a role in signaling pathways
underlying the regulation of apoptosis, cell growth, and angiogenesis. Somatic mutations
in the PIK3CA gene that increase the enzymatic activity of its protein product are
associated with a number of cancer types such as breast, colorectal and ovarian cancers.;
GenBank Accession Number : NM_006218;
Origin ID : C51160;
UMLS CUI : C1709402;
Automatic exact mappings (from CISMeF team)
- OMIM relation
- See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
- gene_found_in_organism
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
