Proto-Oncogene Vav

Preferred Label : Proto-Oncogene Vav;

NCIt synonyms : VAV1; VAV; VAV-1; Vav 1 Guanine Nucleotide Exchange Factor; VAV1 Protein; Guanine Nucleotide Exchange Factor VAV1;

NCIt definition : Proto-oncogene vav (845 aa, 98 kDa) is encoded by the human VAV1 gene. This protein plays a role in the activation of small GTPases in the Rho and Rac families.;

Details

Origin ID

C18283;

UMLS CUI

C1451772;

OMIM relation
- Vav guanine nucleotide exchange factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- VAV1 protein, human [MeSH concept]
- VAV1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Signaling Pathway Gene [NCIt concept]
- VAV1 Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- DAG/PE-Binding Domain [NCIt concept]
- DH Domain [NCIt concept]
- PH Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Phospholipase C Signaling Pathway [NCIt concept]
- Rac1 Cell Motility Signaling Pathway [NCIt concept]
- Ras-Independent Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Cell Activation Process [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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