Preferred Label : DH Domain;
NCIt synonyms : RhoGEF Domain; Dbl Homology Domain; DBL-Homology Domain;
NCIt definition : The Dbl homology (DH) or RhoGEF domain consists of a 150 amino acid region that induces
Rho family GTPases to displace GDP. This effectively activates the Rho GTPase by allowing
binding to GTP, which is in excess over GDP in the cell. The DH domain is invariably
proceeded by a pleckstrin homology (PH) domain. While not absolutely required for
catalysis of nucleotide exchange, the PH domain appears to greatly increase catalytic
efficiency in many cases. Rho proteins control actin dynamics, gene expression, membrane
trafficking, growth factor signaling, and cellular transformation. Proteins encoding
DH domains (RhoGEFs) also play a role in these events as they function as the primary
activators of Rho GTPases. In fact, many RhoGEFs were identified based on their transforming
activity, which was abrogated upon disruption of their DH domain. (Pawson Lab, SLRI,
Mount Sinai Hospital, 2003);
Origin ID : C14076;
UMLS CUI : C1511655;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
