Son of Sevenless Homolog 1

Preferred Label : Son of Sevenless Homolog 1;

NCIt synonyms : SOS-1; SOS1 Guanine Nucleotide Exchange Factor; Guanine Nucleotide Exchange Factor SOS1;

NCIt definition : Son of sevenless homolog 1 (1333 aa, 152 kDa) is encoded by the human SOS1 gene. This protein is involved in the mediation of guanine nucleotide exchange for RAS superfamily proteins.;

Details

Origin ID

C116311;

UMLS CUI

C3890926;

Automatic exact mappings (from CISMeF team)
- SOS Ras/Rac guanine nucleotide exchange factor 1 [ORDO Gene]
- Sos ras/rac guanine nucleotide exchange factor 1 [OMIM gene]
- sos1 protein [MeSH Descriptor]
OMIM relation
- Sos ras/rac guanine nucleotide exchange factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- SOS1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- DH Domain [NCIt concept]
- PH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Angiogenesis Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- CREB Activation Signaling Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Cardiac Hypertrophy Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Dorso-Ventral Axis Formation Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EGFR-Dependent Endothelin Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- HBx Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IGF1 Pathway [NCIt concept]
- IGF1R Antiapoptosis Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2/PI3K Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- IL3 Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- Longevity Pathway [NCIt concept]
- MAP Kinase Downregulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Nerve Growth Factor Pathway [NCIt concept]
- Neuronal Survival Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- PDGFR-alpha Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
- Trka Receptor Signaling Pathway [NCIt concept]
- VEGFR3 Lymphatic Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Post-Translational Modification [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Pan-KRAS Inhibitor BI 1701963 [NCIt concept]
- SOS1 Inhibitor MRTX0902 [NCIt concept]
- SOS1 Inhibitor ZG2001 Tosylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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