Guanine Nucleotide Exchange Factor VAV2

Preferred Label : Guanine Nucleotide Exchange Factor VAV2;

NCIt synonyms : VAV2; VAV2 Gene Product; VAV2 Protein; VAV-2;

NCIt definition : Guanine nucleotide exchange factor VAV2 (878 aa, 101 kDa) is encoded by the human VAV2 gene. This protein plays a role in guanine nucleotide exchange factor activity for Rho family GTPases.;

NCIt note : Guanine nucleotide exchange factor VAV2 contains a calponin-homology domain, a DBL-homology domain, a PH domain, a DAG binding domain, an SH2 domain, and SH3 domains.;

Details

Origin ID

C17921;

UMLS CUI

C0297681;

OMIM relation
- Vav guanine nucleotide exchange factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Signaling Pathway Gene [NCIt concept]
- VAV2 Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- DAG/PE-Binding Domain [NCIt concept]
- DH Domain [NCIt concept]
- PH Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- SH3 Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adherens Junction Formation Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Ephrin A Forward Signaling Pathway [NCIt concept]
- Ephrin A2 Forward Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Erythropoietin Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Phosphoinositide Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Post-Translational Modification [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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