T Cell Receptor Signaling Pathway KEGG

Preferred Label : T Cell Receptor Signaling Pathway KEGG;

NCIt synonyms : TCR Signaling Pathway;

NCIt related terms : T cell receptor signaling pathway;

Alternative definition : KEGG: Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.;

KEGG ID : hsa04660;

Details

Origin ID

C91450;

UMLS CUI

C2984263;

Automatic exact mappings (from CISMeF team)
- T cell receptor signaling pathway [GO term]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- B-Cell Lymphoma/Leukemia 10 [NCIt concept]
- CD40 Ligand [NCIt concept]
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Caspase Recruitment Domain-Containing Protein 11 [NCIt concept]
- Cytoplasmic Protein NCK2 [NCIt concept]
- Cytotoxic T-Lymphocyte Protein 4 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- GRB2-Related Adapter Protein 2 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Granulocyte-Macrophage Colony-Stimulating Factor [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV3 [NCIt concept]
- Inducible T-Cell Costimulator [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interleukin-2 [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-5 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Beta [NCIt concept]
- NF-Kappa-B Inhibitor Epsilon [NCIt concept]
- Nuclear Factor NF-kappa-B p105 Subunit [NCIt concept]
- Nuclear Factor of Activated T-Cells 5 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 1 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 3 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Programmed Cell Death Protein 1 [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- RAS Guanyl-Releasing Protein 1 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase C [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 3 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 4 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 5 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 6 [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Gamma Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Zeta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD4 [NCIt concept]
- T-Cell Surface Glycoprotein CD8 Alpha Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD8 Beta Chain [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Tyrosine-Protein Kinase ITK/TSK [NCIt concept]
- Tyrosine-Protein Kinase Lck [NCIt concept]
- Tyrosine-Protein Kinase TEC [NCIt concept]
- Tyrosine-Protein Kinase ZAP-70 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 6 [NCIt concept]
- [Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 1, Mitochondrial [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- BCL10 wt Allele [NCIt concept]
- CARD11 wt Allele [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CD247 wt Allele [NCIt concept]
- CD28 wt Allele [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E wt Allele [NCIt concept]
- CD3G wt Allele [NCIt concept]
- CD4 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- CD8B wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CSF2 wt Allele [NCIt concept]
- CTLA4 wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- GRAP2 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- ICOS wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IL2 wt Allele [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL5 wt Allele [NCIt concept]
- ITK wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- LAT wt Allele [NCIt concept]
- LCK wt Allele [NCIt concept]
- MALT1 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NCK2 wt Allele [NCIt concept]
- NFAT5 wt Allele [NCIt concept]
- NFATC1 wt Allele [NCIt concept]
- NFATC2 wt Allele [NCIt concept]
- NFATC3 wt Allele [NCIt concept]
- NFATC4 wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NFKBIB wt Allele [NCIt concept]
- NFKBIE wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PAK3 wt Allele [NCIt concept]
- PAK4 wt Allele [NCIt concept]
- PAK5 wt Allele [NCIt concept]
- PAK6 wt Allele [NCIt concept]
- PDCD1 wt Allele [NCIt concept]
- PDK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PPP3R1 wt Allele [NCIt concept]
- PPP3R2 wt Allele [NCIt concept]
- PTPN6 wt Allele [NCIt concept]
- PTPRC wt Allele [NCIt concept]
- RASGRP1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- TEC wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- VAV1 wt Allele [NCIt concept]
- VAV2 wt Allele [NCIt concept]
- VAV3 wt Allele [NCIt concept]
- ZAP70 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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