Serine/Threonine-Protein Kinase PAK 4

Preferred Label : Serine/Threonine-Protein Kinase PAK 4;

NCIt synonyms : p21 CDC42/RAC1-Activated Kinase 4; EC 2.7.11.1; PAK4; PAK-4; p21-Activated Protein Kinase 4; p21-Activated Kinase 4;

NCIt definition : Serine/threonine-protein kinase PAK 4 (591 aa, 64 kDa) is encoded by the human PAK4 gene. This protein plays a role in the phosphorylation of serine/threonine residues, which regulates cell morphology, cytoskeletal organization, cell survival, cell proliferation and migration.;

Details

Origin ID

C178167;

UMLS CUI

C1449211;

Automatic exact mappings (from CISMeF team)
- P21 protein-activated kinase 4 [OMIM gene]
OMIM relation
- P21 protein-activated kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PAK4 protein, human [MeSH Supplementary Concept]
- PAK4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PAK4 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Survival [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- PAK4 Inhibitor PF-03758309 [NCIt concept]
- Padnarsertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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