Focal Adhesion Pathway

Preferred Label : Focal Adhesion Pathway;

NCIt synonyms : Integrin-mediated Cell Adhesion Pathway;

NCIt related terms : Focal Adhesion; Integrin-mediated Cell Adhesion;

Alternative definition : KEGG: Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signaling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signaling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signaling.;

KEGG ID : hsa04510;

Details

Origin ID

C38829;

UMLS CUI

C1512810;

Automatic exact mappings (from CISMeF team)
- cell adhesion mediated by integrin [GO term]
- focal adhesion [GO term]
- focal adhesions [MeSH concept]
- focal adhesions [MeSH Descriptor]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- cell adhesion mediated by integrin [GO term]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- ARF GTPase-Activating Protein GIT2 [NCIt concept]
- Actin, Cytoplasmic 1 [NCIt concept]
- Actin, Cytoplasmic 2 [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- Alpha-Actinin-1 [NCIt concept]
- Alpha-Actinin-4 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- Calpain-2 Catalytic Subunit [NCIt concept]
- Cartilage Oligomeric Matrix Protein [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Caveolin-1 [NCIt concept]
- Caveolin-2 [NCIt concept]
- Caveolin-3 [NCIt concept]
- Cell Division Control Protein 42 Homolog [NCIt concept]
- Collagen Alpha-1(I) Chain [NCIt concept]
- Collagen Alpha-2(I) Chain [NCIt concept]
- Collagen Alpha-2(IV) Chain [NCIt concept]
- Collagen Alpha-3(IV) Chain [NCIt concept]
- Collagen Alpha-3(VI) Chain [NCIt concept]
- Collagen Alpha-6(IV) Chain [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Dedicator of Cytokinesis Protein 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Epithelial Membrane Protein 1 [NCIt concept]
- Epithelial Membrane Protein 2 [NCIt concept]
- Fibronectin [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- G1/S-Specific Cyclin-D3 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV2 [NCIt concept]
- Guanine Nucleotide Exchange Factor VAV3 [NCIt concept]
- Hepatocyte Growth Factor [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Integrin Alpha-1 [NCIt concept]
- Integrin Alpha-10 [NCIt concept]
- Integrin Alpha-2 [NCIt concept]
- Integrin Alpha-3 [NCIt concept]
- Integrin Alpha-4 [NCIt concept]
- Integrin Alpha-5 [NCIt concept]
- Integrin Alpha-6 [NCIt concept]
- Integrin Alpha-9 [NCIt concept]
- Integrin Alpha-IIb [NCIt concept]
- Integrin Alpha-V [NCIt concept]
- Integrin Beta-1 [NCIt concept]
- Integrin Beta-3 [NCIt concept]
- Integrin Beta-4 [NCIt concept]
- Integrin Beta-5 [NCIt concept]
- Integrin Beta-6 [NCIt concept]
- Integrin Beta-7 [NCIt concept]
- Integrin Beta-8 [NCIt concept]
- Integrin-Linked Protein Kinase [NCIt concept]
- Laminin Subunit Alpha-2 [NCIt concept]
- Laminin Subunit Alpha-3 [NCIt concept]
- Laminin Subunit Beta-2 [NCIt concept]
- Laminin Subunit Gamma-2 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Myosin Light Chain Kinase, Smooth Muscle [NCIt concept]
- Osteopontin [NCIt concept]
- Paxillin [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Alpha [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Placenta Growth Factor [NCIt concept]
- Platelet-Derived Growth Factor C [NCIt concept]
- Platelet-Derived Growth Factor D [NCIt concept]
- Platelet-Derived Growth Factor Subunit A [NCIt concept]
- Platelet-Derived Growth Factor Subunit B [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Proto-Oncogene Vav [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- RAS-Related Protein Rap-1A [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 3 [NCIt concept]
- Ras-Specific Guanine Nucleotide-Releasing Factor 1 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Reelin [NCIt concept]
- Rho GTPase-Activating Protein 35 [NCIt concept]
- Rho GTPase-Activating Protein 5 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- Rho-Associated Protein Kinase 2 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- SHC-Transforming Protein 2 [NCIt concept]
- SHC-Transforming Protein 3 [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 3 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 4 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 5 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 6 [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit [NCIt concept]
- Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Tenascin [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
- Vascular Endothelial Growth Factor B [NCIt concept]
- Vascular Endothelial Growth Factor D [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 1 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 3 [NCIt concept]
- Vasodilator-Stimulated Phosphoprotein [NCIt concept]
- Vinculin [NCIt concept]
- Vitronectin [NCIt concept]
- Zyxin [NCIt concept]
- von Willebrand Factor [NCIt concept]
pathway_has_gene_element
- ACTB wt Allele [NCIt concept]
- ACTC1 wt Allele [NCIt concept]
- ACTG1 wt Allele [NCIt concept]
- ACTN1 wt Allele [NCIt concept]
- ACTN4 wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARHGAP35 wt Allele [NCIt concept]
- ARHGAP5 wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BCAR1 wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CAPN2 wt Allele [NCIt concept]
- CAV1 wt Allele [NCIt concept]
- CAV2 wt Allele [NCIt concept]
- CAV3 wt Allele [NCIt concept]
- CCND3 wt Allele [NCIt concept]
- CDC42 wt Allele [NCIt concept]
- COL1A1 wt Allele [NCIt concept]
- COL1A2 wt Allele [NCIt concept]
- COL4A2 wt Allele [NCIt concept]
- COL4A3 wt Allele [NCIt concept]
- COL4A6 wt Allele [NCIt concept]
- COL6A3 wt Allele [NCIt concept]
- COMP wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- DOCK1 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- EMP1 wt Allele [NCIt concept]
- EMP2 wt Allele [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- FLT1 wt Allele [NCIt concept]
- FLT4 wt Allele [NCIt concept]
- FN1 wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- GIT2 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HGF wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- ILK wt Allele [NCIt concept]
- ITGA1 wt Allele [NCIt concept]
- ITGA10 wt Allele [NCIt concept]
- ITGA2 wt Allele [NCIt concept]
- ITGA2B wt Allele [NCIt concept]
- ITGA3 wt Allele [NCIt concept]
- ITGA4 wt Allele [NCIt concept]
- ITGA5 wt Allele [NCIt concept]
- ITGA6 wt Allele [NCIt concept]
- ITGA9 wt Allele [NCIt concept]
- ITGAV wt Allele [NCIt concept]
- ITGB1 wt Allele [NCIt concept]
- ITGB3 wt Allele [NCIt concept]
- ITGB4 wt Allele [NCIt concept]
- ITGB5 wt Allele [NCIt concept]
- ITGB6 wt Allele [NCIt concept]
- ITGB7 wt Allele [NCIt concept]
- ITGB8 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- KDR wt Allele [NCIt concept]
- LAMA2 wt Allele [NCIt concept]
- LAMA3 wt Allele [NCIt concept]
- LAMB2 wt Allele [NCIt concept]
- LAMC2 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MET wt Allele [NCIt concept]
- MYLK wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PAK3 wt Allele [NCIt concept]
- PAK4 wt Allele [NCIt concept]
- PAK5 wt Allele [NCIt concept]
- PAK6 wt Allele [NCIt concept]
- PDGFA wt Allele [NCIt concept]
- PDGFB wt Allele [NCIt concept]
- PDGFC wt Allele [NCIt concept]
- PDGFD wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PGF wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PIP5K1A wt Allele [NCIt concept]
- PPP1CA wt Allele [NCIt concept]
- PPP1CB wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RAC3 wt Allele [NCIt concept]
- RAP1A wt Allele [NCIt concept]
- RAPGEF1 wt Allele [NCIt concept]
- RASGRF1 wt Allele [NCIt concept]
- RELN wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- ROCK2 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SHC2 wt Allele [NCIt concept]
- SHC3 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SPP1 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- TNC wt Allele [NCIt concept]
- VASP wt Allele [NCIt concept]
- VAV1 wt Allele [NCIt concept]
- VAV2 wt Allele [NCIt concept]
- VAV3 wt Allele [NCIt concept]
- VCL wt Allele [NCIt concept]
- VEGFB wt Allele [NCIt concept]
- VEGFD wt Allele [NCIt concept]
- VTN wt Allele [NCIt concept]
- VWF wt Allele [NCIt concept]
- ZYX wt Allele [NCIt concept]

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