Axon Guidance Pathway

Preferred Label : Axon Guidance Pathway;

NCIt related terms : Axon guidance;

Alternative definition : KEGG: Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.;

NCI Metathesaurus CUI : CL453105;

KEGG ID : hsa04360;

Details

Origin ID

C91455;

UMLS CUI

C2984268;

Automatic exact mappings (from CISMeF team)
- Axon Guidance [MeSH concept]
- Axon Guidance [MeSH Descriptor]
- axon guidance [GO term]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- Axon Guidance [MeSH Descriptor]
- axon guidance [GO term]
has_gene_product_element
- C-X-C Chemokine Receptor Type 4 [NCIt concept]
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Cofilin-1 [NCIt concept]
- Cytoplasmic Protein NCK2 [NCIt concept]
- Dihydropyrimidinase-Related Protein 5 [NCIt concept]
- Ephrin Type-A Receptor 1 [NCIt concept]
- Ephrin Type-A Receptor 2 [NCIt concept]
- Ephrin Type-A Receptor 3 [NCIt concept]
- Ephrin Type-A Receptor 4 [NCIt concept]
- Ephrin Type-A Receptor 5 [NCIt concept]
- Ephrin Type-A Receptor 6 [NCIt concept]
- Ephrin Type-A Receptor 8 [NCIt concept]
- Ephrin Type-B Receptor 1 [NCIt concept]
- Ephrin Type-B Receptor 2 [NCIt concept]
- Ephrin Type-B Receptor 3 [NCIt concept]
- Ephrin Type-B Receptor 4 [NCIt concept]
- Ephrin Type-B Receptor 6 [NCIt concept]
- Ephrin-B2 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Integrin Beta-1 [NCIt concept]
- Integrin-Linked Protein Kinase [NCIt concept]
- LIM Domain Kinase 1 [NCIt concept]
- LIM Domain Kinase 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Netrin Receptor DCC [NCIt concept]
- Netrin-1 [NCIt concept]
- Netrin-G1 [NCIt concept]
- Neural Cell Adhesion Molecule L1 [NCIt concept]
- Neuropilin-1 [NCIt concept]
- Nuclear Factor of Activated T-Cells 5 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 1 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 3 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 [NCIt concept]
- Partitioning Defective 6 Homolog Alpha [NCIt concept]
- Plexin-A1 [NCIt concept]
- Plexin-C1 [NCIt concept]
- Protein Patched Homolog 1 [NCIt concept]
- Protein Wnt-5b [NCIt concept]
- Ras GTPase-Activating Protein 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 3 [NCIt concept]
- Regulator of G-Protein Signaling 3 [NCIt concept]
- Rho Guanine Nucleotide Exchange Factor 12 [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- Rho-Associated Protein Kinase 2 [NCIt concept]
- Roundabout Homolog 1 [NCIt concept]
- Roundabout Homolog 2 [NCIt concept]
- Roundabout Homolog 3 [NCIt concept]
- SLIT-ROBO Rho GTPase-Activating Protein 2 [NCIt concept]
- SLIT-ROBO Rho GTPase-Activating Protein 3 [NCIt concept]
- Semaphorin-3D [NCIt concept]
- Semaphorin-3E [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 3 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 4 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 5 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 6 [NCIt concept]
- Short Transient Receptor Potential Channel 6 [NCIt concept]
- Slit Homolog 1 Protein [NCIt concept]
- Slit Homolog 2 Protein [NCIt concept]
- Slit Homolog 3 Protein [NCIt concept]
- Smoothened Homolog [NCIt concept]
- Sonic Hedgehog Protein [NCIt concept]
- Stromal Cell-Derived Factor 1 [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
- Tyrosine-Protein Kinase Fes/Fps [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- ARHGEF12 wt Allele [NCIt concept]
- CFL1 wt Allele [NCIt concept]
- CXCL12 wt Allele [NCIt concept]
- CXCR4 wt Allele [NCIt concept]
- DCC wt Allele [NCIt concept]
- DPYSL5 wt Allele [NCIt concept]
- EFNB2 wt Allele [NCIt concept]
- EPHA1 wt Allele [NCIt concept]
- EPHA2 wt Allele [NCIt concept]
- EPHA3 wt Allele [NCIt concept]
- EPHA4 wt Allele [NCIt concept]
- EPHA5 wt Allele [NCIt concept]
- EPHA6 wt Allele [NCIt concept]
- EPHA8 wt Allele [NCIt concept]
- EPHB1 wt Allele [NCIt concept]
- EPHB2 wt Allele [NCIt concept]
- EPHB3 wt Allele [NCIt concept]
- EPHB4 wt Allele [NCIt concept]
- EPHB6 wt Allele [NCIt concept]
- FES wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- ILK wt Allele [NCIt concept]
- ITGB1 wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- L1CAM wt Allele [NCIt concept]
- LIMK2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MET wt Allele [NCIt concept]
- NCK2 wt Allele [NCIt concept]
- NFAT5 wt Allele [NCIt concept]
- NFATC1 wt Allele [NCIt concept]
- NFATC2 wt Allele [NCIt concept]
- NFATC3 wt Allele [NCIt concept]
- NFATC4 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- NRP1 wt Allele [NCIt concept]
- NTNG1 wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PAK3 wt Allele [NCIt concept]
- PAK4 wt Allele [NCIt concept]
- PAK5 wt Allele [NCIt concept]
- PAK6 wt Allele [NCIt concept]
- PARD6A wt Allele [NCIt concept]
- PLXNA1 wt Allele [NCIt concept]
- PLXNC1 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PPP3R1 wt Allele [NCIt concept]
- PPP3R2 wt Allele [NCIt concept]
- PTCH1 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RAC3 wt Allele [NCIt concept]
- RASA1 wt Allele [NCIt concept]
- RGS3 wt Allele [NCIt concept]
- ROBO1 wt Allele [NCIt concept]
- ROBO2 wt Allele [NCIt concept]
- ROBO3 wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- ROCK2 wt Allele [NCIt concept]
- SEMA3D wt Allele [NCIt concept]
- SEMA3E wt Allele [NCIt concept]
- SHH wt Allele [NCIt concept]
- SLIT1 wt Allele [NCIt concept]
- SLIT3 wt Allele [NCIt concept]
- SMO wt Allele [NCIt concept]
- SRGAP2 wt Allele [NCIt concept]
- SRGAP3 wt Allele [NCIt concept]
- TRPC6 wt Allele [NCIt concept]
- WNT5B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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