" /> Protein Patched Homolog 1 - CISMeF





Preferred Label : Protein Patched Homolog 1;

NCIt synonyms : PTCH; Patched; PTC1; PTC; PTCH1;

NCIt definition : Protein patched homolog 1 (1447 aa, 161 kDa) is encoded by the human PTCH1 gene. This protein is involved in the modulation of hedgehog protein family signaling pathways, embryonic development, and tumor supression.;

NCIt note : Sonic hedgehog binding to protein patched homolog 1 appears to activate the 7-transmembrane protein Smoothened by release from protein patched homolog 1-mediated inhibition. Tumors may be associated with mutations that activate Smoothened or inactivate protein patched homolog 1, causing excess activity of the hedgehog response pathway. (OMIM);

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31/07/2025


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