Hedgehog Signaling Pathway

Preferred Label : Hedgehog Signaling Pathway;

Alternative definition : KEGG: The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes.;

KEGG ID : hsa04340;

Details

Origin ID

C91516;

UMLS CUI

C1155468;

Automatic exact mappings (from CISMeF team)
- smoothened signaling pathway [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- smoothened signaling pathway [GO term]
has_gene_product_element
- Beta-Arrestin-2 [NCIt concept]
- Bone Morphogenetic Protein 2 [NCIt concept]
- Bone Morphogenetic Protein 4 [NCIt concept]
- Casein Kinase I Isoform Alpha [NCIt concept]
- Casein Kinase I Isoform Delta [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- EvC Complex Member EVC [NCIt concept]
- F-Box/WD Repeat-Containing Protein 1A [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Hedgehog-Interacting Protein [NCIt concept]
- Kinesin-Like Protein KIF7 [NCIt concept]
- Limbin [NCIt concept]
- Low-Density Lipoprotein Receptor-Related Protein 2 [NCIt concept]
- Protein Patched Homolog 1 [NCIt concept]
- Protein Patched Homolog 2 [NCIt concept]
- Protein Wnt-16 [NCIt concept]
- Protein Wnt-7a [NCIt concept]
- Smoothened Homolog [NCIt concept]
- Sonic Hedgehog Protein [NCIt concept]
- Speckle-Type POZ Protein [NCIt concept]
- Suppressor of Fused Homolog [NCIt concept]
- Zinc Finger Protein GLI1 [NCIt concept]
- Zinc Finger Protein GLI2 [NCIt concept]
- Zinc Finger Protein ZIC 2 [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
is_target
- Hedgehog Inhibitor NLM-001 [NCIt concept]
pathway_has_gene_element
- ARRB2 wt Allele [NCIt concept]
- BMP2 wt Allele [NCIt concept]
- BMP4 wt Allele [NCIt concept]
- BTRC wt Allele [NCIt concept]
- CSNK1A1 wt Allele [NCIt concept]
- CSNK1D wt Allele [NCIt concept]
- EVC wt Allele [NCIt concept]
- EVC2 wt Allele [NCIt concept]
- GLI1 wt Allele [NCIt concept]
- GLI2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HHIP wt Allele [NCIt concept]
- KIF7 wt Allele [NCIt concept]
- LRP2 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PTCH1 wt Allele [NCIt concept]
- PTCH2 wt Allele [NCIt concept]
- SHH wt Allele [NCIt concept]
- SMO wt Allele [NCIt concept]
- SMURF2 wt Allele [NCIt concept]
- SPOP wt Allele [NCIt concept]
- SUFU wt Allele [NCIt concept]
- WNT16 wt Allele [NCIt concept]
- WNT6 wt Allele [NCIt concept]
- WNT7A wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients