Rho-Associated Protein Kinase 2

Preferred Label : Rho-Associated Protein Kinase 2;

NCIt synonyms : ROCK2; Rho-Associated, Coiled-Coil-Containing Protein Kinase 2; EC 2.7.11.1; Rho-Associated, Coiled-Coil-Containing Protein Kinase II; Rho Kinase 2; Rho-Associated Coiled-Coil-Containing Protein Kinase 2; ROCK-II; p164 ROCK-2;

NCIt definition : Rho-associated protein kinase 2 (1388 aa, 161 kDa) is encoded by the human ROCK2 gene. This protein plays a role in cellular processes that are modulated by Rho signaling pathways.;

Details

Origin ID

C178173;

UMLS CUI

C1742459;

Automatic exact mappings (from CISMeF team)
- Rho-associated coiled-coil-containing protein kinase 2 [OMIM gene]
- follicle stimulating hormone [MeSH Descriptor]
OMIM relation
- Rho-associated coiled-coil-containing protein kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ROCK2 protein, human [MeSH Supplementary Concept]
- ROCK2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- ROCK2 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adherens Junction Stabilization Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- PLK1 Signaling Pathway [NCIt concept]
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Belumosudil [NCIt concept]
- Belumosudil Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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