Tight Junction Assembly Pathway

Preferred Label : Tight Junction Assembly Pathway;

NCIt related terms : Tight junction;

Alternative definition : KEGG: Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutionarily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintenance of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additional scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and RNA processing factors, regulatory proteins like small GTPases and G-proteins, kinases and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways.;

KEGG ID : hsa04530;

Details

Origin ID

C91475;

UMLS CUI

C2984287;

Automatic exact mappings (from CISMeF team)
- Tight junction (cell structure) [SNOMED CT concept]
- bicellular tight junction [GO term]
- tight junction [SNOMED Notion]
- tight junction [GO term]
- tight junctions [MeSH concept]
- tight junctions [MeSH Descriptor]
Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- 5'-AMP-Activated Protein Kinase Subunit Gamma-2 [NCIt concept]
- Actin, Cytoplasmic 1 [NCIt concept]
- Actin, Cytoplasmic 2 [NCIt concept]
- Actin-Related Protein 3B [NCIt concept]
- Afadin [NCIt concept]
- Alpha-Actinin-1 [NCIt concept]
- Alpha-Actinin-4 [NCIt concept]
- Casein Kinase II Subunit Alpha [NCIt concept]
- Claudin-1 [NCIt concept]
- Claudin-18 [NCIt concept]
- Claudin-18 Isoform A2 [NCIt concept]
- Claudin-4 [NCIt concept]
- Claudin-6 [NCIt concept]
- Claudin-7 [NCIt concept]
- Junctional Adhesion Molecule A [NCIt concept]
- Lethal(2) Giant Larvae Protein Homolog 1 [NCIt concept]
- MARVEL Domain-Containing Protein 2 [NCIt concept]
- Membrane-Associated Guanylate Kinase, WW and PDZ Domain-Containing Protein 1 [NCIt concept]
- Membrane-Associated Guanylate Kinase, WW and PDZ Domain-Containing Protein 2 [NCIt concept]
- Merlin [NCIt concept]
- Myosin-1 [NCIt concept]
- Myosin-11 [NCIt concept]
- Myosin-2 [NCIt concept]
- Myosin-9 [NCIt concept]
- Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF1 [NCIt concept]
- Partitioning Defective 3 Homolog [NCIt concept]
- Partitioning Defective 6 Homolog Alpha [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Kinase C Epsilon Type [NCIt concept]
- Protein Kinase C Iota Type [NCIt concept]
- Protein PALS1 [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- RAS-Related Protein Rap-1A [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Ras-Related Protein R-Ras [NCIt concept]
- Ras-Related Protein Rab-8A [NCIt concept]
- Rho-Associated Protein Kinase 1 [NCIt concept]
- Rho-Associated Protein Kinase 2 [NCIt concept]
- SRC Substrate Cortactin [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 55 kDa Regulatory Subunit B Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 55 kDa Regulatory Subunit B Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform [NCIt concept]
- T-Lymphoma Invasion and Metastasis-Inducing Protein 1 [NCIt concept]
- Tight Junction Protein ZO-1 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Tyrosine-Protein Kinase Yes [NCIt concept]
pathway_has_gene_element
- ACTB wt Allele [NCIt concept]
- ACTG1 wt Allele [NCIt concept]
- ACTN1 wt Allele [NCIt concept]
- ACTN4 wt Allele [NCIt concept]
- ACTR3B wt Allele [NCIt concept]
- AFDN wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- CLDN1 wt Allele [NCIt concept]
- CLDN18 wt Allele [NCIt concept]
- CLDN4 wt Allele [NCIt concept]
- CLDN6 wt Allele [NCIt concept]
- CLDN7 wt Allele [NCIt concept]
- CSNK2A1 wt Allele [NCIt concept]
- CTTN wt Allele [NCIt concept]
- F11R wt Allele [NCIt concept]
- LLGL1 wt Allele [NCIt concept]
- MAGI1 wt Allele [NCIt concept]
- MAGI2 wt Allele [NCIt concept]
- MARVELD2 wt Allele [NCIt concept]
- MYH1 wt Allele [NCIt concept]
- MYH11 wt Allele [NCIt concept]
- MYH2 wt Allele [NCIt concept]
- MYH9 wt Allele [NCIt concept]
- NF2 wt Allele [NCIt concept]
- NHERF1 wt Allele [NCIt concept]
- PALS1 wt Allele [NCIt concept]
- PARD3 wt Allele [NCIt concept]
- PARD6A wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PPP2CB wt Allele [NCIt concept]
- PPP2R1A wt Allele [NCIt concept]
- PPP2R2A wt Allele [NCIt concept]
- PPP2R2B wt Allele [NCIt concept]
- PRKAG2 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PRKCE wt Allele [NCIt concept]
- PRKCI wt Allele [NCIt concept]
- RAB8A wt Allele [NCIt concept]
- RAP1A wt Allele [NCIt concept]
- RAPGEF2 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- ROCK1 wt Allele [NCIt concept]
- ROCK2 wt Allele [NCIt concept]
- RRAS wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- TIAM1 wt Allele [NCIt concept]
- TJP1 wt Allele [NCIt concept]
- YES1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients