Afadin - CISMeF

Preferred Label : Afadin;

NCIt synonyms : MLLT4; Trithorax Homolog 4; AF6; Afadin Adherens Junction Formation Factor; AF-6 Protein; Protein AF-6; ALL1-Fused Gene From Chromosome 6 Protein; AF-6; AFDN;

NCIt definition : Afadin (1824 aa, 207 kDa) is encoded by the human AFDN gene. This protein is involved in the formation of adherens junctions.;

NCIt note : Afadin binds and connects nectin and actin in the cytoskeleton.;

Details

Origin ID

C33946;

UMLS CUI

C1505151;

OMIM relation
- Afadin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AFDN protein, human [MeSH Supplementary Concept]
- AFDN protein, human [MeSH concept]
- afadin [MeSH concept]
- afadin [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AFDN Gene [NCIt concept]
- Cytoskeletal Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Zonula Adherens [NCIt concept]
gene_product_has_biochemical_function
- Actin-Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- FHA Domain [NCIt concept]
- PDZ Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Adherens Junction Formation Pathway [NCIt concept]
- Adherens Junction Stabilization Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Nectin Adhesion Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Movement Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Cytoskeletal Process [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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