Zonula Adherens

Preferred Label : Zonula Adherens;

NCIt synonyms : Intermediate Junction; Adherens Junction; AJ;

NCIt definition : The best understood cell-cell junction required for adhesion between cells in the epithelium. It seals adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. Adherens junctions are located most apically in insect cells and just basal to the tight junction in vertebrate cells. It is formed by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence based on homophilic association between molecules of the transmembrane protein E-cadherin, which is linked on its cytoplasmic side to the actin cytoskeleton via b-catenin (Drosophila Armadillo) and a-catenin. The adherens junctions and associated cytoskeleton form a continuous band (zonula adherens) around the apical circumference of each cell, thus uniting the cells of the epithelium into a coherent sheet.;

Details

Origin ID

C13736;

UMLS CUI

C0230613;

Anatomic structure is physical part of
- Cell [NCIt concept]
- Cell Surface [NCIt concept]
- Epithelium [NCIt concept]
Associated anatomy of gene products
- Afadin [NCIt concept]
- Band 4.1-Like Protein 5 [NCIt concept]
- Catenin Alpha-1 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Epidermal Growth Factor Receptor Kinase Pathway Substrate 8-Like Protein 1 [NCIt concept]
- Junction Plakoglobin [NCIt concept]
- Kelch-Like Protein 24 [NCIt concept]
- Nectin-1 [NCIt concept]
- Nectin-2 [NCIt concept]
- Nectin-4 [NCIt concept]
- Protein MB21D2 [NCIt concept]
- Protein PALS1 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase Kappa [NCIt concept]
- Rho GTPase-Activating Protein 24 [NCIt concept]
- Splicing Regulator ARVCF [NCIt concept]
- T-Cell Immunoreceptor with Ig and ITIM Domains [NCIt concept]
Currated CISMeF NLP mapping
- Adherens junction [FMA entity]
- adherens junctions [MeSH Descriptor]
- adherens junctions [MeSH concept]
- intermediate junction [SNOMED Notion]
- zonula adherens [GO term]
- zonula adherens [MeSH concept]
False automatic mappings
- Intermediate junction (cell structure) [SNOMED CT concept]
- adherens junction [GO term]
Semantic type(s)
- Cell Component [UMLS semantic type]
UMLS correspondences (same concept)
- Adhesive belt [FMA entity]
- Intermediate junction (cell structure) [SNOMED CT concept]
- intermediate junction [SNOMED Notion]
- zonula adherens [GO term]
- zonula adherens [MeSH concept]

Keyword's position in hierarchy(ies) :

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