Preferred Label : FHA Domain;
NCIt synonyms : Forkhead-Associated Domain;
NCIt definition : The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found
in many regulatory proteins. It displays specificity for phosphothreonine-containing
epitopes but will also recognize phosphotyrosine with relatively high affinity. It
spans approximately 80-100 amino acid residues folded into an 11-stranded sandwich,
which sometimes contain small helical insertions between the loops connecting the
strands. To date, genes encoding FHA-containing proteins have been identified in eubacterial
and eukaryotic but not aracheal genomes. The domain is present in a diverse range
of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding
proteins and metabolic enzymes which partake in many different cellular processes.
DNA repair, signal transduction, vesicular transport and protein degradation are just
a few examples.;
Origin ID : C13945;
UMLS CUI : C1517093;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
