Antigen KI-67 - CISMeF

Preferred Label : Antigen KI-67;

NCIt synonyms : KIA; MIB-1; Antigen Identified by Monoclonal Antibody Ki-67; Ki-67 Antigen; Proliferation-Related Ki-67 Antigen; MKI67 Protein; MKI67; Proliferation-Related-Ki-67 Antigen;

NCIt related terms : Ki67;

NCIt definition : Antigen KI-67 protein (3256 aa, 359 kDa) is encoded by the human MKI67 gene. This protein is required for cell proliferation.;

NCIt note : Detection of Antigen KI-67 is used to locate proliferating cells in neoplastic diseases. (OMIM); Antigen KI-67 protein expression occurs during late G1, S, G2, and M phases of the cell cycle, while in cells in G0 phase the protein cannot be detected. The protein is located in the perinucleolar region during G1 phase. In the later phases it is detected throughout the nuclear interior, predominantly in the nuclear matrix. In mitosis, it is present on all chromosomes. (SwissProt);

NCI Metathesaurus CUI : CL963711;

Details

Origin ID

C17675;

UMLS CUI

C4742498;

Currated CISMeF NLP mapping
- Ki-67 antigen [MeSH concept]
- ki-67 antigen [MeSH Descriptor]
OMIM relation
- Marker of proliferation ki67 [OMIM gene]
See also inter- (CISMeF)
- Ki-67 nuclear [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ki-67 antigen [MeSH concept]
- Ki-67 nuclear [LOINC component]
- Ki-67 nuclear Ag [LOINC component]
- MKI67 protein, human [MeSH Supplementary Concept]
- ki-67 antigen [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Cycle Gene [NCIt concept]
- MKI67 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- FHA Domain [NCIt concept]
gene_product_is_biomarker_type
- Proliferation Marker [NCIt concept]
gene_product_malfunction_associated_with_disease
- Neoplasm [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation [NCIt concept]

Keyword's position in hierarchy(ies) :

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