Serine/Threonine-Protein Kinase Chk2

Preferred Label : Serine/Threonine-Protein Kinase Chk2;

NCIt synonyms : CHK2 Checkpoint Homolog; CDS1; CHK2 Homolog; Protein Kinase CHK2; CHEK2; Checkpoint-Like Protein CHK2; CHK2; Checkpoint Kinase 2; Cds1 Homolog; Hucds1; Serine-Threonine Protein Kinase-CHK2; EC 2.7.11.1; hCds1;

NCIt definition : Serine/threonine-protein kinase Chk2 (543 aa, 61 kDa) is encoded by the human CHEK2 gene. This protein plays an essential role in the DNA damage checkpoint of the cell cycle.;

Details

Origin ID

C40966;

UMLS CUI

C1259236;

Automatic exact mappings (from CISMeF team)
- Cdp-diacylglycerol synthase 1 [OMIM gene]
- Checkpoint kinase 2 [OMIM gene]
- Checkpoint kinase 2 [OMIM Phenotype]
- checkpoint kinase 2 [MeSH Descriptor]
- checkpoint kinase 2 [HGNC gene]
- checkpoint kinase 2 [MeSH concept]
- checkpoint kinase 2 [ORDO Gene]
OMIM relation
- Checkpoint kinase 2 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CHEK2 protein, human [MeSH Supplementary Concept]
- CHEK2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CHEK2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_gene_product_variant
- CHEK2 NP_009125.1:p.I157T [NCIt concept]
- CHEK2 NP_009125.1:p.S428F [NCIt concept]
- CHEK2 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- FHA Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATM Signaling Pathway [NCIt concept]
- Cancer Susceptibility Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- PLK3 Signaling Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Survival [NCIt concept]
- Negative Regulation of G1 Phase [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
is_target
- Checkpoint Kinase Inhibitor AZD7762 [NCIt concept]
- Checkpoint Kinase Inhibitor XL844 [NCIt concept]
- Chk2 Inhibitor PHI-101 [NCIt concept]
- Rabusertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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