p53 Signaling Pathway KEGG

Preferred Label : p53 Signaling Pathway KEGG;

NCIt related terms : p53 signaling pathway;

Alternative definition : KEGG: p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.;

KEGG ID : hsa04115;

Details

Origin ID

C91495;

UMLS CUI

C2984306;

Automatic exact mappings (from CISMeF team)
- DNA damage response, signal transduction by p53 class mediator [GO term]
Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 14-3-3 Protein Sigma [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Adhesion G Protein-Coupled Receptor B1 [NCIt concept]
- Apoptosis Regulator BAX [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- BH3-Interacting Domain Death Agonist [NCIt concept]
- Bcl-2-Binding Component 3 [NCIt concept]
- CD82 Antigen [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-8 [NCIt concept]
- Caspase-9 [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
- Cytochrome C [NCIt concept]
- DNA Damage-Binding Protein 2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- G1/S-Specific Cyclin-D3 [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Beta [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Insulin-Like Growth Factor-Binding Protein 3 [NCIt concept]
- Phorbol-12-Myristate-13-Acetate-Induced Protein 1 [NCIt concept]
- Protein Phosphatase 1D [NCIt concept]
- Protein Reprimo [NCIt concept]
- Ribonucleoside-Diphosphate Reductase M2 [NCIt concept]
- Ribonucleoside-Diphosphate Reductase Subunit M2 B [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Serine/Threonine-Protein Kinase ATR [NCIt concept]
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]
- Serine/Threonine-Protein Kinase Chk2 [NCIt concept]
- Sestrin-1 [NCIt concept]
- Sestrin-3 [NCIt concept]
- Tuberin [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
- Tumor Protein p73 [NCIt concept]
- p53 Apoptosis Effector Related to PMP-22 [NCIt concept]
- p53-Induced Death Domain-Containing Protein 1 [NCIt concept]
- p53-Regulated Apoptosis-Inducing Protein 1 [NCIt concept]
pathway_has_gene_element
- ADGRB1 wt Allele [NCIt concept]
- APAF1 wt Allele [NCIt concept]
- ATM wt Allele [NCIt concept]
- ATR wt Allele [NCIt concept]
- BAX wt Allele [NCIt concept]
- BBC3 wt Allele [NCIt concept]
- BID wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CCND3 wt Allele [NCIt concept]
- CD82 wt Allele [NCIt concept]
- CDK6 wt Allele [NCIt concept]
- CHEK1 wt Allele [NCIt concept]
- CHEK2 wt Allele [NCIt concept]
- CYCS wt Allele [NCIt concept]
- DDB2 wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- GADD45A wt Allele [NCIt concept]
- GADD45B wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IGFBP3 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- PERP wt Allele [NCIt concept]
- PIDD1 wt Allele [NCIt concept]
- PMAIP1 wt Allele [NCIt concept]
- PPM1D wt Allele [NCIt concept]
- RPRM wt Allele [NCIt concept]
- RRM2 wt Allele [NCIt concept]
- RRM2B wt Allele [NCIt concept]
- SESN1 wt Allele [NCIt concept]
- SESN3 wt Allele [NCIt concept]
- SFN wt Allele [NCIt concept]
- TNFRSF10B wt Allele [NCIt concept]
- TP53AIP1 wt Allele [NCIt concept]
- TP73 wt Allele [NCIt concept]
- TSC2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients